AGE-RELATED MACULAR DEGENERATION
If you’ve noticed a difference in the quality of your central vision, colours losing their vibrancy, straight lines appearing as wavy, or objects seeming smaller than they are, visit an eye care professional who can check for signs of AMD.
Early detection and intervention are key to managing AMD, so it's important not to ignore the potential signs. Here, we’ll be walking you through what AMD could mean for you and give you a better understanding of what can cause it, how it is usually detected and what you can do to improve your eye health.
What is Age-related Macular Degeneration (AMD)?
AMD is a gradual loss of vision in the central portion of the retina, called the macula, that occurs in older age. It usually affects people over 601, which is why it’s referred to as ‘age-related’. This condition impacts your vision from the centre of your eyes, and although it doesn’t usually cause total blindness, it can make everyday activities such as reading and driving more difficult. The majority of people with AMD experience a slow worsening of their vision, in one or both eyes, but the degeneration can occur more quickly for some.
Wet and dry macular degeneration
The most common form of macular degeneration is dry AMD, which involves gradual thinning of the macula and accumulation of small, white or yellowish deposits (drusen) over time. The macula has lots of light-sensitive cells that are essential for vision. As they get used up, new cells are created to replace them. With dry AMD, however, the retinal cells aren’t removed and replaced regularly enough, meaning the old cells build up as drusen, which is typically the cause of worsening central vision.
Wet AMD occurs when new, abnormal blood vessels grow underneath the retina and begin leaking fluid and blood. This is much less common than dry AMD but can be more severe.
Dry AMD normally causes central vision to worsen gradually over time, whereas wet AMD can lead to a sudden and more drastic loss of central vision that can have a bigger impact on your quality of life.
Does AMD affect both eyes?
Macular degeneration will typically affect both eyes, but some people will find that one eye is affected more than the other. Having regular eye tests will ensure that the signs of AMD are detected as early as possible, and your eye care professional will be able to advise you whether one or both eyes are affected, and to what degree.
Causes of age-related macular degeneration (AMD)
AMD is a complex condition that has no exact cause. Several genetic and environmental factors can contribute to a person developing AMD, including age, family history, blood pressure, gender, diet/obesity, and smoking.2
Signs & symptoms of age-related macular degeneration (AMD)
In its earliest stages, dry AMD may not cause any symptoms, and it is only when the signs are detected at a sight test that you may become aware of it. The macula is the part of the retina that we use for central vision, so people who suffer from AMD usually report that reading becomes difficult, colours become less vibrant, and recognising faces is more difficult. It can occur suddenly, but most people experience a slow change in their vision, with one eye more affected than the other. With wet AMD, you might experience symptoms and signs such as a loss of central vision much earlier, which make it easier to spot yourself. It’s important to note that AMD isn’t painful, so be sure to see an eye care professional if your eyes begin to hurt or if you experience any other symptoms.
Some symptoms of AMD may include3:
- Blurred or distorted vision (central part of vision, not peripheral)
- Seeing waviness to what should otherwise be straight lines
- Colours appear less vibrant than they used to
- Objects appear smaller than usual
How is AMD diagnosed?
Your eye care professional may use various tests to get a better look at the back of the eyes, the most common being the dilated eye exam, which involves using eye drops to widen the pupils. This allows eye care professionals to examine the retina in more detail and spot early AMD signs such as drusen or changes to the retina’s pigment.
Fundus photography can also create a snapshot of how healthy your retina is since it highlights the size and extent of any drusen or pigmentation differences over time.
Another advanced imaging technique used often is Optical Coherence Tomography (OCT), which provides cross-sectional imagery of the retina. This gives eye care professionals detailed insights into the health of your retinal layers and can help them spot any potential damage caused by AMD. This newer, non-invasive method is now considered the preferred option for diagnosing certain types of AMD and monitoring its progression.
Using these tests, eye care professionals can determine whether AMD is present, and if it is, they can pinpoint which stage it is in, which type of AMD you have, and the best course of action moving forward to protect your vision.
Management and available treatment for age-related macular degeneration (AMD)
People who smoke, have a poor diet or have a family history of AMD are at a higher risk of developing the condition. As an age-related condition, it is difficult to prevent, but you can support your overall eye health and vision by eating a good, balanced diet, as well as taking nutritional supplements for your eyes and cutting down on, or stopping, smoking. Supplements containing antioxidants and zinc may help slow the progression of this condition for some, particularly those dealing with dry AMD.3
Dietary supplements are not a substitute for a healthy, balanced diet but can be useful to ensure that the daily recommended intake of essential vitamins and minerals is achieved. People who are taking any medication or are pregnant or breastfeeding should always seek the advice of a healthcare professional before taking any dietary supplements.
Eating a diet rich in antioxidants and macular pigments, such as Lutein and Zeaxanthin, plus Omega-3 fatty acids, including oily fish such as salmon, mackerel and sardines, or flaxseed oil, may help reduce the risk of development and progression of AMD.3 You can also support your nutritional intake with specially formulated supplements. Nutrof® Total from the Théa product range is a supplement containing lutein and zeaxanthin which can support macular health. It also contains zinc, which may help with maintaining normal vision. We always recommend seeking the advice of you eye care professional before taking any supplements.
It has also been shown that eye exposure to ultraviolet (UV) radiation from the sun, could lead to an increased risk of developing AMD too.4,5 Therefore, it is advisable to wear sunglasses, or lenses with a UV filter, and a hat with a wide brim when out and about, even on bright overcast days, to help protect your eyes.
Those experiencing wet AMD are likely to be offered treatment with anti-angiogenic agents that help to reduce or even prevent the growth of new blood vessels under the macula. Although this isn’t aimed at restoring normal vision, this treatment can potentially go a long way in reducing the risk of further deterioration.6,7 Otherwise, without treatment, wet AMD can lead to significant vision loss.
We always recommend seeking the help of your eyecare professional should you notice any changes or have any concerns relating to your eye health.
Age-related Macular Degeneration FAQs
References:
1. Age-related macular degeneration (AMD) - NHS (www.nhs.uk)
2. NICE Guideline (NG82) (2018) Age-related Macular Degeneration. Available at: Overview | Age-related macular degeneration | Guidance | NICE
3. Chew EY et al. AREDS2 Research Group. Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28. JAMA Ophthalmol. 2022 Jul 1;140(7):692-698.
4. Amari B et al.. LIFETIME AMBIENT ULTRAVIOLET RADIATION EXPOSURE AND INCIDENCE OF AGE-RELATED MACULAR DEGENERATION. Retina. 2024 Jan 1;44(1):28-36.
5. Qu Y, et al,. Association of exposure to ultraviolet radiation and warm-season ozone air pollution with incident age-related macular degeneration: A nationwide cohort study in China. Sci Total Environ. 2024 Aug 15;938:173580.
6. Heloterä H, Kaarniranta K. A Linkage between Angiogenesis and Inflammation in Neovascular Age-Related Macular Degeneration. Cells. 2022 Nov 1;11(21):3453.
7. Singh M et al. Age-Related Macular Degeneration (AMD): Pathophysiology, Drug Targeting Approaches, and Recent Developments in Nanotherapeutics. Medicina (Kaunas). 2024 Oct 8;60(10):1647.
8. Eye conditions and driving: If you have a bus, coach or lorry licence - GOV.UK (www.gov.uk)